Where To Buy Calcium D Glucarate
My dr. told me I needed to increase my calcium. In researching, this type seems to be the best combo in adding to my other supplements. Love the quality of Seeking Health without all the other additives.
where to buy calcium d glucarate
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In supplement form, calcium and glucaric acid are combined to stabilize the glucaric acid in supplement form. Once calcium D-glucarate enters your stomach it is metabolized to calcium and glucaric acid. Glucaric acid is the active ingredient in this supplement, which means it is the ingredient that provides the most benefit for your hormones.
Calcium D-glucarate does contain about 9% calcium, which is not a substantial amount and will not replace the need for dietary calcium or a calcium supplement. Calcium citrate and calcium glycinate are better forms of calcium to supplement with for bone, nervous system, cardiovascular, and muscle health.
Oral calcium d-glucarate supplementation has been shown to prevent the body from reabsorbing and recycling hormones and harmful environmental toxins. It does this by supporting increased glucuronidation (phase 2 liver detoxification) and inhibiting beta-glucuronidase, which facilitate the secretion of potentially harmful compounds and hormones. More on all of this soon.
Calcium D-glucarate plays an important role in elimination of the products the liver has prepared for excretion. To understand how calcium D-glucarate benefits your hormones we need to get a little nerdy with liver metabolism. Stick with me because liver health is everything in having awesome hormones.
By inhibiting beta-glucuronidase activity, calcium D-glucarate may help prevent the increase in toxic metabolites and facilitate the elimination of estrogen by the body. Of the different metabolites of glucaric acid, calcium D-glucarate appears to have the longest inhibitory effect on beta-glucuronidase.
Hair loss can be caused for a variety of reasons and excess estrogen can be one of them. If this is the case, calcium D-glucarate may help assist your body with the removal of hormones responsible for hair loss.
While calcium D-glucarate shows some promise with regards to breast, colon, lung, skin, and prostate cancer, it is important to note that most studies are done on animals or within a lab. We need more robust research to understand the impact this may have.
In a 2007 mouse study published in Oncology Letters it was found that calcium D-glucarate supplementation halted lung tumor growth by inducing apoptosis (death of the cells) and reducing inflammation.
Calcium D-glucarate has also shown promise in fighting skin cancer in animal models. In a 2007 study published in the Journal of Environmental Pathology, Toxicology, and Oncology it was found that supplementing with calcium D-glucarate inhibited the progression of skin cancer via apoptosis.
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First of all, what is Calcium D-glucarate? It is the calcium salt of D-glucarate, a compound made in the body through the oxidation of glucose. D-glucarate is also found naturally in grapefruit, apples, oranges, and cruciferous vegetables. (1,2) Calcium D-glucarate is also made in the body.
In order to keep you healthy, your body needs to go through the process of detoxification. D-glucarate can help inhibit enzymes that reverse the detoxification process, helping your body detox the way it should.
It can also encourage a healthy inflammatory response and offer antioxidant protection. (4-6)Calcium D-glucarate has been shown to support normal cell division in laboratory studies. (7-9)
Calcium D-glucarate is important because it helps ensure that estrogen marked for excretion actually leaves the body. Without sufficient levels of calcium D-glucarate, the neutralized hormone can be activated and reabsorbed in the body. The liver then has to work again on clearing the reintroduced hormone, which strains the liver.
Calcium D-glucarate ensures that the processed hormone or toxin is excreted by inhibiting beta-glucaronidase from recycling the hormones. If beta-glucaronidase is too prevalent, you may reabsorb more estrogen than you need. As we age, this is exactly what occurs.
Calcium D-glucarate is an important part of a successful intervention because it promotes better function of the liver and intestines. In addition to detoxifying the body generally, the liver cleans the extracellular matrix (ECM). The ECM is where all the signaling between cells occurs, including the transmission of hormones. The way to clear estrogen or other hormones out of the extracellular matrix is through the liver. If the liver is able to efficiently eliminate excess hormones from the body, it will be able to handle other chemicals, including toxins, more efficiently as well. Thus, by helping the liver with estrogen excretion, calcium D-glucarate not only combats estrogen dominance, it also strengthens overall liver function, so that balance can be achieved for all components of the NEM Stress Response.
Calcium D-glucarate helps the body excrete hormones, ultimately rebalancing the NEM stress response by ensuring that what the liver marked as toxic stays out of the body. But remember that optimizing liver function requires a comprehensive approach. In addition to Calcium D-glucarate, other natural compounds such as fermented forms of milk thistle, dandelion, and artichoke leaf should be part of your liver optimization program as well.
So if you suspect you have estrogen dominance, which many women do without knowing it, calcium D-glucarate might be a good supplement to consider. It works by inhibiting the enzyme that reactivates hormones your liver has already neutralized and marked for excretion. That way, excess estrogen can be flushed out of your system.
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Calcium D-glucarate is a calcium salt of D-glucaric acid, a non-toxic compound found in many fruits and vegetables, especially grapefruits, apples, oranges and even cruciferous vegetables, such as broccolini and Collard greens, but in trace amounts. (1)
Oral supplementation of Calcium D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microbiota heavily involved in liver detoxification. (4) This inhibitory enzyme can be produced in excessive amounts when our microbiome is compromised by a pathogenic bacterial foothold.
Supposedly, enter the supplement, calcium D-glucarate, to the rescue. Studies indicate that calcium D-Glucarate will actually prevent the excess beta-glucuronidase from cleaving the end-products of estrogen, allowing them to remain glucuronidated and to be excreted properly.
In mice models, D-glucarates themselves appear to suppress cell proliferation and inflammation, and can also induce cell apoptosis, that is, they can potentially support proper cell death so as to keep malignancy in check. (11)
For the most part, Calcium-D-Glucarate is just known to be a β-glucuronidase inhibitor via its metabolite D-glucaro-1,4-lactone. The process of 'glucuronidation' is a detoxification process where a group (known as a glucuronide) is attached to a hydrophobic molecule to make it more water soluble, and then the kidneys can better facilitate its removal from the body. This process is positively mediated by the glucuronosyltransferase enzyme, and negatively mediated by the β-glucuronidase enzyme; as such, inhibiting the negative regulator (the enzyme that removes the glucuronide) indirectly increases the activity of this pathway. 041b061a72